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Year : 2021  |  Volume : 31  |  Issue : 1  |  Page : 6-10

Assessment of pulmonary arterial hemodynamic and vascular changes by pulmonary pulse transit time in patients with human immunodeficiency virus infection

1 Department of Cardiology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
2 Department of Cardiology, Kocaeli University, Kocaeli, Turkey
3 Department of Infectious Diseases and Clinical Microbiology, Hacettepe University, Ankara, Turkey
4 Department of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey
5 Department of Infectious Diseases and Clinical Microbiology, Atilim University, Ankara, Turkey

Correspondence Address:
Mehmet Akif Erdol
Üniversiteler Mahallesi 1604, Cadde No: 9 Çankaya/Ankara, University of Health Sciences, Ankara City Hospital, Ankara 06800
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcecho.jcecho_103_20

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Introduction: Pulmonary arterial hypertension and human immunodeficiency virus (HIV) infection is a well-known association. Pulmonary pulse transit time (pPTT) is a recent echocardiographic marker that might be used for evaluation of pulmonary arterial stiffness (PAS) in patients with HIV infection. We aimed to investigate whether pPTT elevated in patients with HIV infection compared to healthy controls and its association with echocardiographic indices of right ventricular functions. Materials and Methods: Fifty HIV (+) patients from infectious disease outpatient clinics and fifty age- and sex-matched HIV (−) healthy volunteers were enrolled in this study. pPTT was measured from pulmonary vein flow velocity as the time interval between the R-wave in the electrocardiography and corresponding peak late systolic was then calculated as the mean from two separate pw-Doppler measurements. Results: pPTT, tricuspid annular peak systolic excursion (TAPSE) and right ventricle fractional area change (FAC) were significantly lower in patients with HIV than control patients (177.1 ± 34.9 vs. 215.7 ± 35.7 msn, P < 0.001; 2.33 ± 0.28 vs. 2.19 ± 0.22, P = 0.039; 45 [4.25] vs. 41.1 [4.0], P = 0.032, respectively). pPTT was positively correlated with FAC, TAPSE and cluster of differentiation 4 count (r = 0.210; P = 0.036, r = 0.256; P = 0.041, r = 0.304; P = 0.044, respectively). Conclusion: Our study showed that pPTT, TAPSE, and right ventricle FAC levels were lower in patients with HIV infection. pPTT is an important predictor in patients with HIV expected to develop pulmonary vascular pathology.

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