|Year : 2017 | Volume
| Issue : 3 | Page : 114-117
Subsequent safe pregnancy with cesarean delivery in a patient with a history of peripartum takotsubo syndrome complicated by cardiogenic shock
Rodolfo Citro1, Michele Bellino1, Flora Minichino2, Davide Di Vece1, Donatella Ferraioli1, Raffaele Petta3
1 Department of Cardiology, University Hospital “San Giovanni di Dio e Ruggi d'Aragona”, Salerno, Italy
2 Division of Anesthesiology, University Hospital “San Giovanni di Dio e Ruggi d'Aragona”, Salerno, Italy
3 Division of Obstetrics and Gynecology, University Hospital “San Giovanni di Dio e Ruggi d'Aragona”, Salerno, Italy
|Date of Web Publication||4-Jul-2017|
University Hospital “San Giovanni di Dio e Ruggi d'Aragona”, Heart Tower. Room 810, Largo Citta di Ippocrate, 84131 Salerno
Source of Support: None, Conflict of Interest: None
Takotsubo syndrome (TTS) is an acute and reversible heart failure syndrome, usually occurring in females but rarely in the peripartum period. In women with a history of peripartum TTS, it is unclear how to manage subsequent pregnancies. A 39-year-old female with a history of peripartum TTS complicated by cardiogenic shock became pregnant again. She underwent close cardiological follow-up for monitoring left ventricular systolic function and hemodynamic conditions. Epidural anesthesia was preferred to avoid catecholamine surge during cesarean delivery. After a few days of hospitalization, the patient and the newborn were discharged in good health. In our patient with a history of complicated peripartum TTS, close cardiological follow-up, appropriate management therapy, and anesthesia modality allow us to guide safely a new pregnancy.
Keywords: Caesarian section, peripartum cardiomyopathy, spinal anesthesia, stress cardiomyopathy, Takotsubo syndrome
|How to cite this article:|
Citro R, Bellino M, Minichino F, Di Vece D, Ferraioli D, Petta R. Subsequent safe pregnancy with cesarean delivery in a patient with a history of peripartum takotsubo syndrome complicated by cardiogenic shock. J Cardiovasc Echography 2017;27:114-7
|How to cite this URL:|
Citro R, Bellino M, Minichino F, Di Vece D, Ferraioli D, Petta R. Subsequent safe pregnancy with cesarean delivery in a patient with a history of peripartum takotsubo syndrome complicated by cardiogenic shock. J Cardiovasc Echography [serial online] 2017 [cited 2021 May 16];27:114-7. Available from: https://www.jcecho.org/text.asp?2017/27/3/114/209549
| Introduction|| |
Takotsubo syndrome (TTS), also known as stress cardiomyopathy or “broken heart syndrome,” is a clinical entity characterized by transient left ventricular (LV) systolic dysfunction and reversible heart failure,, usually involving the apex (apical ballooning) and less commonly, the midventricular and basal LV walls. TTS is associated with a relatively good long-term prognosis, as complete recovery of LV systolic function occurs within days or weeks. However, heart failure, cardiogenic shock, and other serious cardiac complications have been reported during the acute phase. Coronary vasospasm, activation of alpha- and beta-adrenergic receptors, neurogenic myocardial stunning, and microvascular dysfunction have been suggested as potential mechanisms. Although the etiology is still unknown, catecholamines seem to play a key role in the pathogenesis of this intriguing syndrome. TTS is often precipitated by an acute emotional or physical stress , and is most prevalent among postmenopausal women though increasingly reported in younger patients including premenopausal women during pregnancy or childbirth., Several cases of peripartum TTS have been described in young women experiencing serious complications after cesarean section.,, Conversely, only a few cases of pregnant women with a history of peripartum TTS are reported in the literature. Crucial issues that remain to be elucidated are (i) whether patients with previous peripartum TTS should be discouraged from becoming pregnant again, (ii) how this patient population should be followed up during pregnancy and postpartum, and (iii) what is the most appropriate anesthesia modality for cesarean delivery.
| Case Report|| |
A 39-year-old female with no relevant anamnestic data apart from a history of peripartum TTS occurred ~4 years previously, became pregnant again. At the time of the first pregnancy, she was admitted to our hospital at 40 weeks of gestation for spontaneous delivery, as described by our group ( first case). However, after a long and very painful labor, she underwent cesarean section under spinal anesthesia because of cephalopelvic disproportion. Subsequently, intravenous oxytocin was administered to stimulate uterine contraction. The following day, she complained of increasing dyspnea and developed cardiogenic shock, requiring diuretics, inotropic drugs, and intra-aortic balloon pumping. Coronary arteries were normal. Echocardiography and left ventriculography showed midventricular ballooning and severely reduced LV systolic function. After complete recovery of myocardial contraction, the patient was discharged after 12 days in good health with a diagnosis of peripartum TTS. Between the two pregnancies, she was in good health, taking only beta-blockers for 1 year thereafter. Despite this tremendous experience, she decided to carry the second pregnancy to term.
On the first visit, at 8 weeks of gestation, the patient was asymptomatic, blood pressure was 110/70 mmHg, and heart rate was 80 bpm. Auscultation revealed normal heart sounds, with no cardiac murmurs or pulmonary rales. No ankle swelling was observed. The electrocardiogram (ECG) showed normal sinus rhythm. Transthoracic echocardiography showed normal LV dimensions with good systolic function (ejection fraction 63%). In addition, speckle tracking echocardiography was performed to evaluate global longitudinal strain (GLS) considered an objective index of myocardial deformation. A GLS value of −24% (n.v. <−19.9%) was detected ruling out early subclinical myocardial dysfunction. No signs of diastolic dysfunction and/or increased LV filling pressure were detected. Trivial mitral and tricuspid regurgitation were observed. Pulmonary arterial pressure was within normal limits. No pericardial effusion was appreciated. The patient was informed about the risk of complicated TTS recurrence during the peripartum period and the current lack of guidelines for the management of this challenging situation.
The multidisciplinary team composed by a cardiologist, an anesthesiologist, and a gynecologist decided not to discourage the pregnancy continuation, considering good cardiovascular condition of the patient.
The primary goal was to avoid the events that had previously triggered TTS onset such as painful labor and spinal anesthesia., The multidisciplinary team met to discuss delivery timing, the most appropriate anesthesia modality, and pre- and post-operative monitoring. Frequent cardiological, ECG, and echocardiographic follow-up during pregnancy were substantially unchanged. Owing to the normal course of pregnancy and normal fetal growth, the patient was hospitalized on week 38 of gestation for elective cesarean delivery. Considering the history of peripartum TTS and to select the most appropriate anesthesia technique, three goals had to be met: to minimize sympathetic activation, to reduce catecholamine surge, and to maintain hemodynamic stability avoiding vasoconstrictor drugs.,
Although spinal anesthesia is the preferred regional technique for cesarean section due to simplicity of technique, rapid administration, and onset of anesthesia, it results in more profound and rapid sympathetic block.,,, Hypotension following spinal anesthesia is more pronounced in pregnant patients because of increased cephalad spread due to aortocaval compression, compression of the dural sac by the engorged epidural venous plexus, and a reduction in lumbosacral cerebrospinal fluid volume. On these grounds, epidural anesthesia was chosen. This modality provides a slow, smooth, and effective anesthetic block with better hemodynamic stability, avoiding abrupt blood pressure drop and perioperative increased serum level of catecholamines.
At the entrance to the operating room, vital signs were good (blood pressure 108/66 mmHg, oxygen saturation 98%, and body temperature 36.6°C). ECG monitoring demonstrated sinus rhythm with heart rate of 78 bpm.
Under local anesthesia, an epidural catheter was inserted at L3–L4 space and a test dose of 3 ml of lidocaine 2% without epinephrine was injected.
For intraoperative anesthesia, 18 mL ropivacaine 0.75% +10 mcg sufentanil +2 mL saline were given epidurally. A microbolus of 2 mL of solution, for a total of 14 mL, was administered every 2 min until extension of sensory block to T4–S1 was obtained. Cesarean section was started 20 min later. During surgery time (35 min), no vasoconstrictors were necessary as blood pressure variations never exceeded 20%. A term male infant was born, with a birth weight of 3600 g and an Apgar score of 9, 10, and 10 at 1, 5, and 10 min, respectively.
Umbilical cord blood gas analysis revealed an arterial pH of 7.29 and a venous pH of 7.38. After newborn extraction and hysterotomy closure, intravenous oxytocin (5 IU over 5 min followed by 20 IU in 1000 mL saline over 8 h) was administered to minimize cardiovascular effects (hypotension, QTc prolongation, and arrhythmias). No adverse events occurred during surgery.
Three hours later, as sensory block was below T6 and motor block was almost resolved (Bromage score 2), epidural analgesia through an elastomeric pump was initiated with ropivacaine 0.2% and sufentanil 0.5 mcg/mL at a 5 mL/h infusion rate over 48 h.
In the postoperative period, pain control, as assessed by visual analog scale, was satisfying.
Vital signs and hemoglobin level were continuously monitored. Serial ECGs performed during the following 48 h were within normal limits. Frequent ultrasound chest scanning, performed every 2 h for the first 24 h using a pocket-size device, revealed no wall motion abnormalities and good LV systolic function. On the 3rd day, the patient was in good clinical condition, and transthoracic echocardiography with speckle tracking analysis confirmed normal systolic function (ejection fraction 64%, GLS −24%) [Figure 1]. The parturient was discharged on the 7th day without cardiovascular therapy. Cardiological evaluation, ECG, and echocardiographic parameters were substantially unchanged at 1, 3, and 6 months of follow-up [Table 1]. At 1-year clinical follow-up, the mother and the newborn were both in good health. Patient's written informed consent to report the case has been obtained.
|Figure 1: Two-dimensional and speckle tracking echocardiography 3 days after cesarean delivery. Apical four-chamber (a), two-chamber (b), and long-axis (c) views by conventional echocardiography (ejection fraction 64%). The time-longitudinal strain curves in the same apical view (e-g) are displayed. The left ventricle is divided into six segments in the long-axis apical view (d), and the segmental global longitudinal strain value is overlaid onto the two-dimensional image. Bull's eye plot (h) displays the regional value of longitudinal strain for 17 segments, and the global longitudinal strain is averaged (−24%)|
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| Discussion|| |
Recently, TTS has been divided into primary and secondary forms, depending on the trigger event and the clinical picture at onset. In particular, secondary TTS often occurs in patients hospitalized for other pathologies who experience an important stress condition (i.e., intensive pain). Cesarean delivery, labor, and abortion have already been reported as possible triggers of secondary pregnancy-related TTS. Peripartum TTS should be included in the differential diagnosis with other diseases associated with pregnancy, such as peripartum cardiomyopathy (PPCM), eclampsia, HELLP syndrome (H: hemolysis, EL: elevated liver enzymes, LP: low platelet count), viral myocarditis, acute coronary dissection, and pheochromocytoma., To distinguish TTS from PPCM is crucial because of important differences between these two conditions. Compared with TTS, PPCM presents the following features: (1) it usually affects patients with cardiovascular risk factors between the last month of pregnancy and the 6 months after delivery, while TTS symptoms occur early after delivery; (2) it generally causes LV dilatation with depressed systolic function due to diffuse hypokinesis, while in 80% of cases TTS is characterized by hypo-, a-, or dyskinesia of the apical region (ballooning) along with the hypercontractile state of basal segments of the LV; (3) it can be successfully managed with beta-adrenergic inotropes, which are contraindicated in TTS; (4) LV recovery takes longer than in TTS and is incomplete in many patients, with persistent LV systolic dysfunction even at long-term follow-up; and (5) recurrences may develop during subsequent pregnancies, which for this reason are often discouraged, particularly in women with signs or symptoms of heart failure including persistent systolic dysfunction and elevation of biomarkers such as NT-proBNP and troponin. Conversely, in patients with a history of peripartum TTS, subsequent pregnancy should not be systematically discouraged. In this setting, women who become pregnant again should undergo close cardiological follow-up. Owing to its large availability and versatility, conventional echocardiography allows continuous monitoring of LV systolic function and hemodynamic conditions, both during pregnancy and postpartum. In addition, speckle tracking echocardiography enables early identification of subclinical myocardial dysfunction before signs and symptoms of heart failure become apparent. Moreover, bedside echoscopy with pocket-size ultrasound devices is useful to evaluate cardiac function in the operating room and in the early postoperative period.
Before cesarean section, careful selection of the anesthesia technique is another key point. Compared with spinal anesthesia, epidural anesthesia provides a more gradual onset of blockade favoring hemodynamic stability. Finally, it is also important to reduce catecholamine release to avoid or minimize the use of vasoconstrictor or sympathomimetic agents.
| Conclusion|| |
In our patient with a history of previous TTS complicated by cardiogenic shock, close cardiological and echocardiographic follow-up, appropriate management therapy and anesthesia modality, allowed us to guide safely the subsequent pregnancy, the childbirth with cesarean section, and the postpartum period. Although we reported only a single case, it should be of interest to spread the message that a new pregnancy should be followed with caution but not systematically discouraged in this peculiar setting. During delivery avoiding or minimizing the effect of potential triggers could play a crucial role. For this reason, epidural anesthesia should be preferred for cesarean section. Our conclusion needs to be confirmed in larger series.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy: A new form of acute, reversible heart failure. Circulation 2008;118:2754-62.
Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, et al.
Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation 2005;111:472-9.
Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, et al.
Current state of knowledge on Takotsubo syndrome: A Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2016;18:8-27.
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, et al.
Clinical features and outcomes of Takotsubo (Stress) cardiomyopathy. N Engl J Med 2015;373:929-38.
Citro R, Rigo F, D'Andrea A, Ciampi Q, Parodi G, Provenza G, et al.
Echocardiographic correlates of acute heart failure, cardiogenic shock, and in-hospital mortality in tako-tsubo cardiomyopathy. JACC Cardiovasc Imaging 2014;7:119-29.
Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, et al.
Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-48.
Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy – A novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 2008;5:22-9.
Citro R, Giudice R, Mirra M, Petta R, Baldi C, Bossone E, et al.
Is Tako-tsubo syndrome in the postpartum period a clinical entity different from peripartum cardiomyopathy? J Cardiovasc Med (Hagerstown) 2013;14:568-75.
Citro R, Pascotto M, Provenza G, Gregorio G, Bossone E. Transient left ventricular ballooning (tako-tsubo cardiomyopathy) soon after intravenous ergonovine injection following caesarean delivery. Int J Cardiol 2010;138:e31-4.
Kraft K, Graf M, Karch M, Felberbaum R. Takotsubo syndrome after cardiopulmonary resuscitation during emergency cesarean delivery. Obstet Gynecol 2017;129:521-4.
Guerci P, Novy E, Vial F, Lecointe B, Geffroy-Bellan M, Longrois D, et al.
Sulprostone for postpartum hemorrhage in a parturient with a history of Tako-tsubo cardiomyopathy. J Clin Anesth 2013;25:327-30.
Citro R, Giudice R, Mirra M, Bottiglieri G, Bossone E, Di Benedetto G, et al.
Tako-tsubo syndrome soon after caesarean delivery: Two case reports. Int J Cardiol 2012;161:e48-9.
Crimi E, Baggish A, Leffert L, Pian-Smith MC, Januzzi JL, Jiang Y. Images in cardiovascular medicine. Acute reversible stress-induced cardiomyopathy associated with cesarean delivery under spinal anesthesia. Circulation 2008;117:3052-3.
Pavón-Benito A, Pérez-Bergara E, Dufur-Mendívil M, Salvador-Bravo M. Pharmacologic preventive strategies for Takotsubo stress cardiomyopathy. What does evidence tell us? Rev Esp Anestesiol Reanim 2015;62:176-7.
Liu S, Bravo-Fernandez C, Riedl C, Antapli M, Dhamee MS. Anesthetic management of Takotsubo cardiomyopathy: General versus regional anesthesia. J Cardiothorac Vasc Anesth 2008;22:438-41.
Hessel EA 2nd
, London MJ. Takotsubo (stress) cardiomyopathy and the anesthesiologist: Enough case reports. Let's try to answer some specific questions! Anesth Analg 2010;110:674-9.
Tunçalp O, Souza JP, Gülmezoglu M; World Health Organization. New WHO recommendations on prevention and treatment of postpartum hemorrhage. Int J Gynaecol Obstet 2013;123:254-6.
Citro R, Lyon AR, Meimoun P, Omerovic E, Redfors B, Buck T, et al.
Standard and advanced echocardiography in Takotsubo (stress) cardiomyopathy: Clinical and prognostic implications. J Am Soc Echocardiogr 2015;28:57-74.
Sliwa K, Hilfiker-Kleiner D, Petrie MC, Mebazaa A, Pieske B, Buchmann E, et al.
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail 2010;12:767-78.
Hilfiker-Kleiner D, Haghikia A, Nonhoff J, Bauersachs J. Peripartum cardiomyopathy: Current management and future perspectives. Eur Heart J 2015;36:1090-7.
Elkayam U. Risk of subsequent pregnancy in women with a history of peripartum cardiomyopathy. J Am Coll Cardiol 2014;64:1629-36.
Tops LF, Delgado V, Marsan NA, Bax JJ. Myocardial strain to detect subtle left ventricular systolic dysfunction. Eur J Heart Fail 2017;19:307-13.