|Year : 2014 | Volume
| Issue : 3 | Page : 78-82
Association of corrected QT and QT dispersion with echocardiographic and laboratory findings in uremic patients under chronic hemodialysis
Arsalan Khaledifar1, Ali Momeni1, Katayoun Hasanzadeh1, Masoud Amiri2, Morteza Sedehi3
1 Department of Internal Medicine, Nephrology Division, Social Health Determinants Research Center, Iran
2 Department of Epidemiology and Biostatistics, Social Health Determinants Research Center, Iran
3 Department of Biostatistics and Epidemiology, School of Health, Shahrekord University of Medical Sciences, Iran
|Date of Web Publication||5-Nov-2014|
Department of Internal Medicine, Hajar Hospital, Shahrekord
Source of Support: None, Conflict of Interest: None
Introduction: Cardiovascular disease is the most common cause of mortality in dialysis patients. Chronic renal failure and hemodialysis (HD) patients may have longer corrected QT (QTc) interval compared with the normal population. Long QTc interval may be a predictor of ventricular arrhythmia and cardiovascular mortality in these patients and hence the aim of this study was the evaluation of the relationship between QTc interval and some echocardiographic findings and laboratory exam results in HD patients. Materials and Methods: In a cross-sectional study, 60 HD patients with age >18 years and the dialysis duration >3 months were enrolled. Blood samples were taken, and electrocardiography and echocardiography were done before the dialysis session in the patients. Results: Mean age of the patients was 56.15 ± 14.6 years. QTc interval of the patients was 0.441 ± 0.056 s and QT dispersion (QTd) was 64.17 ± 25.93 ms. There was no statistically significant relationship between QTc interval and QTd with duration of dialysis, body mass index, age, and gender (P > 0.05). There was also no significant relationship between QTc interval and QTd with mitral regurgitation, tricuspid regurgitation and aortic insufficiency (P > 0.05). In addition, QTc interval and QTd of the patients had not any correlation with serum parathormon and serum Ca, K, HCO 3 (P > 0.05). Conclusion: Based on our results, in HD patients, QTc interval and QTd were not correlated with echocardiographic findings or laboratory exam results. Therefore, it can be concluded that QTc interval prolongation probably has not any correlation with cardiac mortality of the HD patients.
Keywords: Corrected QT interval, echocardiography, hemodialysis, QT dispersion
|How to cite this article:|
Khaledifar A, Momeni A, Hasanzadeh K, Amiri M, Sedehi M. Association of corrected QT and QT dispersion with echocardiographic and laboratory findings in uremic patients under chronic hemodialysis. J Cardiovasc Echography 2014;24:78-82
|How to cite this URL:|
Khaledifar A, Momeni A, Hasanzadeh K, Amiri M, Sedehi M. Association of corrected QT and QT dispersion with echocardiographic and laboratory findings in uremic patients under chronic hemodialysis. J Cardiovasc Echography [serial online] 2014 [cited 2021 Jan 21];24:78-82. Available from: https://www.jcecho.org/text.asp?2014/24/3/78/143972
| Introduction|| |
Cardiovascular disease is the most common cause of mortality in dialysis patients that is responsible for about 60% of their mortality and is also 30 times more common than in general population. , Different cardiovascular disorders, such as left ventricular hypertrophy (LVH), coronary artery diseases, congestive heart failure (CHF), and arterial hypertension are commonly seen in these patients. , In addition, calcification of cardiac valves are common and may cause valvular and annular thickening that in turn could lead to valvular stenosis or regurgitation.  Some predisposing factors of cardiac disorders in dialysis patients are secondary hyperparathyroidism, long term hypertension, and anemia. 
Different electrocardiographic abnormality may be seen in dialysis patients, such as ST, T change, ventricular and supra-ventricular arrhythmia and QT interval prolongation. In the electrocardiogram, QT interval is the time between the start of the Q wave and the end of the T wave. When heart rate increased then QT interval was decreased, so QT interval could be corrected with heart rate. There are a number of different correction formulas, but the standard clinical correction is to use Bazett's formula (QT/√R-R, where R-R is the RR interval in seconds). The normal corrected QT (QTc) interval for males and females are ≤430 ms and ≤450 ms, respectively. The borderline QTc for a male is 431-450 and borderline QTc for a female is 451-470 and the abnormal QTc range for a male is >450 and for a female is >470.  The QTc interval could be prolonged due to electrolyte abnormalities (hypomagnesaemia and hypokalemia), drug consumption (antihistaminic, antiarrhythmic, and antibiotics), brain trauma and genetic abnormalities (long QT syndrome).  Patients with chronic renal failure and dialysis patients had a greater QTc interval and QT dispersion (QTd) (QTd = QTmax - QTmin) compared with the normal population.  A single session of HD could be increased QTc in patients undergoing HD.  Moreover, QT interval may be a predictor of ventricular arrhythmia and cardiovascular mortality in chronic kidney disease and dialysis patients. 
Although there are some studies about QTc and QTc dispersion in hemodialysis (HD) patients with different results; however, there are only a few studies concerning relationship of QTc internal and QTd with echocardiography findings, so the aim of this study was the evaluation of these relationship in dialysis patients.
| Materials and methods|| |
In a cross-sectional study, 60 HD patients with age >18 years and the dialysis duration >3 months were enrolled. Exclusion criteria were : a0 ntiarrhythmic drugs consumption, history of cardiac diseases such as arrhythmia, heart block or CHF. Before dialysis session, electrocardiography (ECG) and echocardiography were done for all of the patients. In the 12 leads, ECG QTc were measured based on Bazett's formula. Also, QTd was measured by mentioned formula (QTd = QTmax - QTmin) in 12 leads ECG. The patients were on HD, by Fresenius digital machine (4008B, Germany) and Gambro digital machine (AK95 and AK96, Sweden), 2-3 times/week, as a regular method (4-4.5 h with blood flow of 250-350 mL/min, dialysate flow of 500 ml/min and ultra-filtration based on the patient's condition). The used buffer was bicarbonate powder, and the type of filters were intermediate and high efficient polysulfone membrane (R5, R6) made by SOHA factory under license of Fresenius Company. Serum creatinine, hemoglobin, Ca, parathyroid hormone (PTH), Na, K, HCO 3 , and pH were checked by RA1000 machine (made in Italy).
All laboratory tests were done before the dialysis session and were checked in a single laboratory. Echocardiography and ECG were done before the dialysis session and by single cardiologist and technician respectively. All data and information were confidential, and for ECG and echocardiography taking an informed consent was taken from each patient.
In echocardiography, left ventricular ejection fraction (LVEF), LVH, pulmonary artery pressure (PAP) and valvular disorders were evaluated. At the end of the study, data were analyzed using SPSS software (version 19, IBM Corporation). P < 0.05 was considered as significant level. Pearson correlation coefficient, two-independent samples t-test and ANOVA were used for statistical analysis. This study was approved by Ethical Committee of Shahrekord University of Medical Sciences with the Grant Number of 904.
| Results|| |
In 60 patients, 37 were males and 23 females. Mean age of the patients were 56.15 ± 14.6 years. Mean body mass indexes (BMIs) (post dialysis) and duration of dialysis were 21.77 ± 3.6 kg/m 2 and 4.25 ± 3.24 years respectively [Table 1]. Mean QTc interval of the patients was 0.441 ± 0.056 s; however, QTc interval in men and women were 0.43 ± 0.04 s and 0.45 ± 0.07 s, respectively (P > 0.05). QTd in all of the patients was 64.17 ± 25.93 ms, however in men and women were 62.70 ± 28.05 ms and 66.52 ± 22.48 ms respectively (P = 0.87). Mean urea reduction ratio in men and women were 68.14% ± 9.34% and 68.22% ± 3.88%; however, Kt/V was 1.45 ± 0.17 and 1.49 ± 0.16 among men and women, respectively.
|Table 1: Characteristics of patients and their association with QTc and QTd |
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There was no statistically significant relationship between QTc interval or QTd with duration of dialysis, BMI, age, and gender (P > 0.05). In ECG, LVH was seen in 23 (38.3%) patients and ST change in 14 patients (23.3%). In echocardiography, mitral regurgitation (MR), tricuspid regurgitation (TR), and aortic insufficiency (AI) were found in 54, 47, and 11 patients respectively [Table 2]. In addition, no significant relation was found between QTc interval and QTd with MR, TR, AI, LVH, septal thickness (ST) and PAP [Table 3]. QTc interval and QTd has also no correlation with serum PTH or Ca, K or HCO 3 .
|Table 3: Echocardiographic findings and their association with QTc and QTd |
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| Discussion|| |
Our findings revealed that, in HD patients, QTc interval and QTd had not any correlation with valvular disorders (MR, AI, and TR), LVH or other echocardiographic findings such as PAP and ST. Furthermore, there was no relationship between QTc interval and QTd with serum Ca, K, HCO 3 , PTH.
In HD patients, cardiac abnormalities such as vascular calcification are common and are associated with the development of LVH, that may cause increased cardiac arrhythmias and mortality. , Elevation of calcium-phosphorus product can also cause valvular calcification and stenosis in these patients. Mitral and aortic calcification and stenosis are common in these patients; however, tricuspid and pulmonic valve calcification is rare. Valvular abnormality could increase the patients' morbidity and mortality. , QTc interval prolongation in chronic kidney disease and HD patients was shown in some studies such as Covic et al. and Ljutic et al. studies which postdialysis QTc interval was 434 ± 29 ms and 445.7 ± 36.9 ms respectively, , while in our patients QTc interval was 444.6 ± 54.5 ms. Selby and McIntyre in a review article reported that HD can increase QTc interval and QTd and is also capable of inducing arrhythmias and increasing mortality especially in patients with ischemic heart disease.  In Nakamura et al. study on 48 dialysis patients, throughout the follow-up period, there was a higher incidence of cardiovascular death in patients with prolongation of QTc dispersion after HD.  Kantarci et al. showed that the serum potassium was significantly higher in HD patients when compared to continuous ambulatory peritoneal dialysis (CAPD) patients and rate of QT interval dispersions was significantly higher in HD and CAPD patients when compared with healthy controls. They concluded that there is a tendency to cardiac arrhythmias in HD patients during the postdialysis period.  Maule et al. showed that after the HD session, QTc increased in 56% and decreased in 43% of the patients but it was not related to the presence of autonomic neuropathy.  After dialysis session, cell-associated Mg levels and QTd increased significantly in Averbukh et al. study, so he concluded that excess daily Mg intake and increased concentrations of cell-associated Mg could be responsible for QTc prolongation in these patients.  Change in serum electrolytes during HD may also be responsible at least partially, to increase QTc or QTd. For example, increase of QTc interval after a dialysis session, and its correlation with plasma calcium level, postdialysis blood pressure, LVEF and ST was shown in Covic et al. study.  Cupisti et al. showed that QTd increased during HD due to serum K + depletion and then return to baseline 2 h after the end of dialysis. QT prolongation during dialysis may also predispose to arrhythmia especially in the cardiac disease patients,  Nδppi et al. demonstrated that HD increases QTd if a low-calcium dialysate is used. Therefore, use of a low-calcium dialysate may predispose HD patients to ventricular arrhythmias.  Genovesi et al. in his study on 16 HD patients showed that QTc interval has a reverse correlation with K + and Ca 2+ concentrations of dialysate.  However, in HD children, Ozdemir et al. found that QTc interval has no correlation with the patients' sex, age and presence of hypertension or LVH but patients with left ventricular systolic dysfunction had significantly greater QTc dispersion. Similar to our study, the changes in serum Ca or K of the patients during dialysis were not associated with the QTc interval in this study.  Moreover, in Hekmat et al.'s study on 49 HD patients, QTc interval had not correlation with serum electrolytes and blood gas findings.  In Voiculescu et al. study, there was no statistically significant correlation between QT interval and serum concentrations of Mg, PO 4 in HD patients too. In addition, QTc interval was not dependent from LVEF, arrhythmias or sudden death.  Our results had some similarities with some of above-mentioned studies as well as some differences with the others. The observed controversy between our study and some of these studies might be due to the discrepancy in the number of cases or racial differences of the patients, and more importantly, the fact that we did not compare predialysis and postdialysis QTc interval.
We could not find any study on the correlation of QTc interval with LVH or valvular heart disease in HD patients; however, there are some studies related to the correlation of QTc and LVH with other diseases or conditions. For example, Mayet et al. reported that QTd has correlated with left ventricular mass index in hypertensive individuals.  Lonati et al. found that in athletes, LVH induced by physical training activity is not associated with an increase in QTd, whereas pathological increase in LVH secondary to hypertension could increase QTd.  The study of Dimopoulos et al. on the evaluation of QTd and left ventricular mass index in elderly hypertensive and normotensive patients reported that hypertensive patients had greater left ventricular mass index and higher QTd. QTd were also found to be independent predictors of left ventricular mass index.  The study had some limitations such as small sample size and lack of QTc measurement after HD session and comparison of it before and after procedure.
| Conclusion|| |
By our knowledge, this is one of the first studies on the correlation of QTc or QTd with valvular abnormality and LVH in HD patients. There were a few studies about the relationship of QTc and LVH in nonrenal patients, so we could not compare our results with other studies. Based on our results, in HD patients, QTc interval or QTd was not correlated with echocardiographic findings or laboratory exam results. Therefore, it can be concluded that QTc interval prolongation probably has not any correlation with cardiac mortality of the HD patients.
| References|| |
|1.||Herzog CA. Cardiac arrest in dialysis patients: Approaches to alter an abysmal outcome. Kidney Int Suppl 2003 May:S197-200. |
|2.||Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, et al. Chronic kidney disease and mortality risk: A systematic review. J Am Soc Nephrol 2006;17:2034-47. |
|3.||Gussak I, Gussak HM. Sudden cardiac death in nephrology: Focus on acquired long QT syndrome. Nephrol Dial Transplant 2007;22:12-4. |
|4.||Takeda K, Harada A, Okuda S, Fujimi S, Oh Y, Hattori F, et al. Sudden death in chronic dialysis patients. Nephrol Dial Transplant 1997;12:952-5. |
|5.||Straumann E, Meyer B, Misteli M, Blumberg A, Jenzer HR. Aortic and mitral valve disease in patients with end stage renal failure on long-term haemodialysis. Br Heart J 1992;67:236-9. |
|6.||Rubel JR, Milford EL. The relationship between serum calcium and phosphate levels and cardiac valvular procedures in the hemodialysis population. Am J Kidney Dis 2003;41:411-21. |
|7.||Wagner G. Marriott's Practical Electrocardiography. Lippincott Williams and Wilkins; 11 th edition. October 31, 2007. |
|8.||Bazett HC. The time relations of the blood-pressure changes after excision of the adrenal glands, with some observations on blood volume changes. J Physiol 1920;53:320-39. |
|9.||Kantarci G, Ozener C, Tokay S, Bihorac A, Akoglu E. QT dispersion in hemodialysis and CAPD patients. Nephron 2002;91:739-41. |
|10.||Morris ST, Galiatsou E, Stewart GA, Rodger RS, Jardine AG. QT dispersion before and after hemodialysis. J Am Soc Nephrol 1999;10:160-3. |
|11.||Cupisti A, Galetta F, Morelli E, Tintori G, Sibilia G, Meola M, et al. Effect of hemodialysis on the dispersion of the QTc interval. Nephron 1998;78:429-32. |
|12.||Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ, et al. Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int 2005;67:217-26. |
|13.||Harnett JD, Kent GM, Barre PE, Taylor R, Parfrey PS. Risk factors for the development of left ventricular hypertrophy in a prospectively followed cohort of dialysis patients. J Am Soc Nephrol 1994;4:1486-90. |
|14.||Baglin A, Hanslik T, Vaillant JN, Boulard JC, Moulonguet-Doleris L, Prinseau J. Severe valvular heart disease in patients on chronic dialysis. A five-year multicenter French survey. Ann Med Interne (Paris) 1997;148:521-6. |
|15.||Gruppen MP, Groothoff JW, Prins M, van der Wouw P, Offringa M, Bos WJ, et al. Cardiac disease in young adult patients with end-stage renal disease since childhood: A Dutch cohort study. Kidney Int 2003;63:1058-65. |
|16.||Covic A, Diaconita M, Gusbeth-Tatomir P, Covic M, Botezan A, Ungureanu G, et al. Haemodialysis increases QT(c) interval but not QT(c) dispersion in ESRD patients without manifest cardiac disease. Nephrol Dial Transplant 2002;17:2170-7. |
|17.||Ljutic D, Sardelic S, Bagatin J, Pivac N, Rumboldt Z. QT interval as a marker of venous reactivity in dialysis patients. Acta Med Croatica 1998;52:39-41. |
|18.||Selby NM, McIntyre CW. The acute cardiac effects of dialysis. Semin Dial 2007;20:220-8. |
|19.||Nakamura S, Ogata C, Aihara N, Sasaki O, Yoshihara F, Nakahama H, et al. QTc dispersion in haemodialysis patients with cardiac complications. Nephrology (Carlton) 2005;10:113-8. |
|20.||Maule S, Veglio M, Mecca F, Calvo C, Martina G, Marangella M, et al. Autonomic neuropathy and QT interval in hemodialysed patients. Clin Auton Res 2004;14:233-9. |
|21.||Averbukh Z, Rosenberg R, Galperin E, Berman S, Cohn M, Cohen N, et al. Cell-associated magnesium and QT dispersion in hemodialysis patients. Am J Kidney Dis 2003;41:196-202. |
|22.||Cupisti A, Galetta F, Caprioli R, Morelli E, Tintori GC, Franzoni F, et al. Potassium removal increases the QTc interval dispersion during hemodialysis. Nephron 1999;82:122-6. |
|23.||Näppi SE, Virtanen VK, Saha HH, Mustonen JT, Pasternack AI. QTc dispersion increases during hemodialysis with low-calcium dialysate. Kidney Int 2000;57:2117-22. |
|24.||Genovesi S, Dossi C, Viganò MR, Galbiati E, Prolo F, Stella A, et al. Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients. Europace 2008;10:771-7. |
|25.||Ozdemir D, Mese T, Agin H, Calkavur S, Bak M. Impact of haemodialysis on QTc dispersion in children. Nephrology (Carlton) 2005;10:119-23. |
|26.||Hekmat R, Bahrami A, Ahmadi M, Nazari H. The effect of the type of hemodialysis buffer on the QTc interval in patients on chronic hemodialysis. Iran J Med Sci 2009;34:29-35. |
|27.||Voiculescu M, Ionescu C, Ismail G. Frequency and prognostic significance of QT prolongation in chronic renal failure patients. Rom J Intern Med 2006;44:407-17. |
|28.||Mayet J, Shahi M, McGrath K, Poulter NR, Sever PS, Foale RA, et al. Left ventricular hypertrophy and QT dispersion in hypertension. Hypertension 1996;28:791-6. |
|29.||Lonati LM, Magnaghi G, Bizzi C, Leonetti G. Patterns of QT dispersion in athletic and hypertensive left ventricular hypertrophy. Ann Noninvasive Electrocardiol 2004;9:252-6. |
|30.||Dimopoulos S, Nicosia F, Donati P, Prometti P, De Vecchi M, Zulli R, et al. QT dispersion and left ventricular hypertrophy in elderly hypertensive and normotensive patients. Angiology 2008;59:605-12. |
[Table 1], [Table 2], [Table 3]