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CASE REPORT
Year : 2019  |  Volume : 29  |  Issue : 2  |  Page : 71-74

Multimodality imaging diagnosis of multiple ventricular thrombosis and massive stroke after gemcitabine and cisplatin chemotherapy for Urothelial Cancer


1 Department of Cardiology, University College of Dublin, Mater Misericordiae University Hospital, Dublin, Republic of Ireland; Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy
2 Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy

Correspondence Address:
Pier Paolo Bassareo
University College of Dublin, Mater Misericordiae University Hospital, Eccles St, Inns Quay, Dublin 7, D07 R2WY, Dublin

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcecho.jcecho_12_19

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Cancer and chemotherapy are known to be risk factors for developing coagulative disorders, venous thrombosis, adverse cardiovascular events, and cardiotoxicity. Combined modality gemcitabine–cisplatin chemotherapy is often administered to treat a few solid tumors. We report the unusual case of a man suffering from urothelial cancer and admitted for chemotherapy, who developed an ischemic stroke after the last chemotherapeutical cycle. During his hospital stay, at echocardiographic examination, left ventricular transient hypokinesia and two intraventricular thrombi were detected, without evidence of acute coronary syndrome. Multimodality imaging approach (i.e., transthoracic echo, transoesophageal echo, computed tomography, and cardiac magnetic resonance imaging) played a pivotal role for a clear diagnosis and prompt decision-making. This is the first report of an intraventricular-related arterial thromboembolic event in a patient treated with the combination gemcitabine–cisplatin.


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